Should you have to shed weight and you’re on the lookout for a prescription weight loss medicine , you have a lot of choices. Your physician may speak with you about Belviq, Qsymia, Saxena or a different medication named CONTRAVE (bupropion and naltrexone). Here is what you want to understand about CONTRAVE, such as expenses, weight loss outcomes, and unwanted side effects.
What Is CONTRAVE?
CONTRAVE is a blend of two distinct medicines: naltrexone hydrochloride and bupropion hydrochloride. Each extended-release pill contains:
Eight mg of ranked best gainers, an opioid agonist That’s often prescribed for alcohol addiction, opioid addiction, or for smoking cessation therapy
90 mg of bupropion, an aminoketone antidepressant That’s used to treat depression and seasonal affective disorder
The mix of both drugs is prescribed to enhance weight loss. The medication affects your central nervous system to boost the amount of calories you burn off and lower your appetite. The pills are prescribed alongside that a reduced-calorie diet and exercise plan to assist certain men and women eliminate weight.
CONTRAVE is fabricated by Orexigen and is dispersed by Takeda.
Who Can Take CONTRAVE?
CONTRAVE is accepted to assist obese adults using a body mass index (BMI) of 30 or higher or obese adults with a BMI of 27 or higher who have a minumum of one weight-related illness such as hypertension, type 2 diabetes, obesity or higher blood pressure.
Certain individuals shouldn’t take CONTRAVE. Refrain from medication for those who:
Have uncontrolled high blood pressure
Have a seizure disorder, anorexia nervosa, or bulimia
Are experiencing abrupt withdrawal from alcohol or other medications (such as benzodiazepines, barbiturates, and antiepileptic medicines )
Are taking other medicines that contain bupropion (like Wellbutrin and Aplenzin)
Are a recurring opioid user
Are pregnant or pregnant
Are allergic to some of the components of CONTRAVE
You should also not take CONTRAVE through or within 14 days of taking monoamine oxidase inhibitors (MAOI).
Researchers don’t understand how taking CONTRAVE impacts your long-term cardiovascular wellness. Therefore, if you’re already at risk for cardiovascular disease, you might choose to consult with your physician about the possibility of injury should you choose this diet pill. The drugmaker is conducting research to determine how the diet pill interacts with heart health, but outcomes aren’t due until 2021.
Last, researchers also don’t understand the way CONTRAVE interacts with additional weight loss products like prescription drugs, over-the-counter medications, and herbal nutritional supplements. Make sure you let your physician know if you’re taking any prescription or non-prescription therapy when you talk about whether the medicine is ideal for you.
CONTRAVE Weight Loss Results
According to clinical trials, CONTRAVE can help promote weight reduction, however, the numbers are not staggering. In a study of individuals without diabetes, 42 percent of patients lost at least 5% of the body weight following a year. Meaning that many people taking CONTRAVE didn’t meet the 5% target.
In a different study, 57 percent of individuals who obtained CONTRAVE dropped at least 5% of the body weight. However, 42 percent of the research participants dropped from the program prior to the study has been finished. Most dropped out over the first couple of weeks.
In individuals with diabetes, the amounts are small too. Thirty-six percentage of patients lost at least 5% of the body weight following a year. In the two studies (patients with and without diabetes) the team taking placebo dropped significantly less weight compared to patients carrying CONTRAVE. All patients in both groups obtained lifestyle modification which consisted of a low-carb diet and normal exercise.
So what exactly does this mean to you? It is important to keep in mind that in every study, patients carrying CONTRAVE were making adjustments to their diet and workout program. Therefore, even though they did lose some weight with the diet pill (approximately 12 lbs in about a year) some of the weight loss resulted from lifestyle changes (diet and exercise) rather than the medication.
Hence, the quantity of fat you lose might possess a fantastic deal to do with how well you keep up a healthful, calorie-controlled diet and an exercise plan.
CONTRAVE Risks and Side Effects
The most frequent side effects reported by patients taking CONTRAVE include nausea, vomiting, constipation, headache, nausea, dizziness, sleeplessness, dry skin, and nausea. From the clinical trials, 24 percent of individuals stopped taking CONTRAVE due to side effects. Just 12 percent of people taking the placebo discontinued therapy.
Black Box Warning
CONTRAVE is needed to take a black box warning saying that consumers must be cautious about a higher risk of suicidal thoughts and behaviours in teens and young adults. Individuals who have suffered from mania or depression might see their conditions reunite while on CONTRAVE.
Since the drug is now approved by the FDA, many medical specialists have voiced concern regarding the prospect of cardiovascular risk. Others have expressed frustration on tv advertisements that minimize the dangers and side effects of CONTRAVE.
Because of this, in 2017, the U.S. Food and Drug Administration issued a warninginto the drugmaker saying that the way in which the television advertising was organised”undermines the communication of important risk information and thereby misleadingly minimizes the risks associated with the use of Contrave” The company goes on to say “The presentation in the video is especially problematic from a public health perspective given the serious and potentially life-threatening risks associated with the drug.”
If you discover the organization’s advertisements appealing and if you think about taking CONTRAVE, make sure you inform your healthcare provider about each medicine you’re taking as you will find a few hazardous conditions that may happen when specific medications interact with this. As soon as you’ve begun taking the weight loss pill, speak with your physician about any unusual symptoms. Following 12 weeks when you haven’t lost at least 5% of your body fat, your physician will likely quit your therapy with the medication since it isn’t probable that this medicine will work for you.
The amount of all CONTRAVE diet pills that you take daily will choose the total price. In accordance with prescribing information supplied by the business, your dosage is very likely to change as you continue with this treatment.
When you first begin accepting CONTRAVE, you might take only 1 pill every day. As you continue the medicine, the dose generally raises. During week two, you just take a single pill in the daytime and one at nighttime. During week three, you just take two pills in the daytime and one at nighttime. After four months, the dose can rise to four pills every day, two per day and 2 at night.
You might discover that the expense of CONTRAVE varies from approximately $99 a month to over $250 a month depending upon dose, place, and insurance policy. The drugmaker supplies a discount voucher program for individuals whose insurance doesn’t insure CONTRAVE or who don’t have insurance policy. Together with all the savings card, then you could have the ability to cover no more than $4 per day to get a monthly prescription.
A Word From Verywell
Weight loss may be hard. A diet pill seems like the ideal solution. However, there isn’t any weight loss medication which works perfectly for everybody. Speak with your doctor about your diet plan and workout experience along with your medical history to find out if CONTRAVE may do the job for you. In case you choose to provide this medicine a go, remain in touch with your health team if you notice unusual signs or symptoms and keep your strong devotion to healthy eating and regular physical activity to ensure your body remains healthy and strong as you lose weight.